盐酸羟考酮对老年癌痛患者的临床效果观察

目的观察盐酸羟考酮治疗老年患者癌痛的临床效果和安全性,为其临床应用提供参考依据。方法将我院2011年12月～2012年12月收治的96例老年晚期癌痛患者随机分为对照组和观察组,每组48例,观察组给予盐酸羟考酮控释片镇痛,对照组给予硫酸吗啡控释片镇痛。治疗8周后,观察和比较两组的镇痛效果和不良反应。结果治疗前,两组VAS评分的差异无统计学意义（P〉0.05）;治疗后,两组的VAS评分均较治疗前显著降低（P〈0.05）,但两组间的差异无统计学意义（P〉0.05）。观察组的平均用药量、解救剂量及不良反应发生数均显著低于对照组（P〈0.05）。结论盐酸羟考酮控释片用于老年癌痛时的镇痛效果与硫酸吗啡控释片相当,但药物用量和副反应更少,在老年晚期癌痛治疗中具有较高的临床应用价值。

Observation on the Clinical Effects of Oxycodone Hydrochloride on Elderly Patients with Advanced Cancer Pain

Objective To analyze the clinical effect and safety of Oxycodone Hydrochloride on elderly patients with cancer pain. Methods Ninty-six elderly patients with advanced cancer pain hospitalized between December 2011 and December 2012 were selected and divided into two groups, 48 patients in each group. The observation group was given Oxycodone hydro- chloride retard-20 tablet analgesia, and the control group was treated by Morphine Sulfate Controlled-release Tablets-20 tablet analgesia. After 8 weeks＇ treatment, the analgesic effect, medicine dose and adverse reactions were compared between the two groups. Results Before treatment, no significant difference was found in VAS score between the two groups （P〉0.05）. After 8 weeks＇ treatment, the VAS scores of two groups both sigmficantly decreased, but there was no statistically significant difference between the two groups （P〉 0.05）. The average medicine dose, save dose and adverse reactions in the observation group were all evidently less than those of the control group （P〈 0.05）. Conclusion Oxycodone Hydrochloride Controlled-release Tablets had equal analgesic effect as Morphine Sulfate Controlled-release Tablets, but with less dosage and adverse reactions, so it had a better clinical value.