食管癌新辅助放化疗疗效观察

目的探讨新辅助放化疗治疗食管癌的临床效果。方法将156例食管癌患随机分为两组，每组78例，对照组采用单纯手术治疗，试验组采用手术联合辅助性放化疗治疗，观察比较两组患者的近期临床疗效及远期疗效。结果试验组的近期总有效率为76．92％，显著高于对照组的48．71％（P〈0．05）。试验组转移复发率为11．54％，显著低于对照组的38．46％（P〈0．05）。结论新辅助放化疗联合手术治疗食管癌的近期疗效较好，远期复发率较低，值得在临床推广应用。

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Objectives To investigate the curative effects of neoadjuvant chemoradiotherapy on esophagus cancer. Methods 156 esophagus cancer patients were randomly divided into the experimental group and control group, and each group had 78 patients. The control group was treated with surgery alone and the experimental group was treated with surgery plus neoadjuvant chemoradiotherapy. The short-term and long-term clinical efficacy of the two groups were observed and compared. Results The short-term total effective rate of the experimental group was 76.92 %, significantly higher than that （48.71%） of the control group （P 〈 0.05）. The metastasis and recurrence rate of the experimental group was 11.54 %, significantly lower than that （38.46 %） of the control group （P〈0.05）. Conclusions Neoadjuvant chemoradiotherapy combined surgical treatment can improve the short-term and long-term clinical efficacy of esophagus cancer. It is worthy of widely clinical application.