| NGAL在原位胰腺癌裸鼠中的表达 |
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| 引用本文： | 蒋富兵,黄进团,余静喜,等. NGAL在原位胰腺癌裸鼠中的表达[J]. 肿瘤药学, 2013, 0(3): 185-187,195 |
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| 作者姓名： | 蒋富兵 黄进团 余静喜 等 |
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| 作者单位： | 惠州市第三人民医院外一科,广东惠州516002 |
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| 摘 要： | 目的研究NGAL在原位胰腺癌裸鼠及正常裸鼠中的表达情况。方法构建原位胰腺癌裸鼠模型,采用ELISA、RT-PCR和Western Blot等方法测定原位胰腺癌裸鼠及正常裸鼠NGAL的血清水平及在外周血白细胞中的表达情况。结果原位胰腺癌裸鼠的血清NGAL水平、外周血白细胞NGAL mRNA表达水平及蛋白表达水平均显著高于正常裸鼠（P〈0.05）。结论原位胰腺癌裸鼠中NGAL的表达增加,胰腺癌可促进裸鼠的NGAL表达上调。
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| 关 键 词： | 裸鼠 原位胰腺癌 NGAL 表达 |
The Expression of NGAL in Nude Mice with Orthotopic Pancreatic Cancer |
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| Jiang Fubing,Huang Jintuan,Yu Jingxi,et al.. The Expression of NGAL in Nude Mice with Orthotopic Pancreatic Cancer[J]. Anti-Tumor Pharmacy, 2013, 0(3): 185-187,195 |
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| Authors: | Jiang Fubing Huang Jintuan Yu Jingxi et al. |
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| Affiliation: | (The First Surgery Department, the Third People＇ s Hospital of Huizhou, Huizhou, Guangdong, 516002, China) |
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| Abstract: | Objective To study the expression ofneutrophil gelatinase associated hpocahn （N（AAL） In nude mace with ortno-topic pancreatic cancer. Methods Building nude mouse model of orthotopic pancreatic cancer. ELISA, RT-PCR and Western blot were used to detect the serum levels of NGAL in normal nude mice and the ones with orthotopic pancreatic cancer, as well as their expression levels in peripheral white blood cells. Results The serum NGAL levels and the mRNA/protein expression levels of NGAL in peripheral WBC of nude mice with orthotopic pancreatic cancer were significantly higher than those of the normal nude mice （P〈0.05）. Conclusions The expression of NGAL is increased in nude mice with orthotopic pancreatic cancer. The pancreatic cancer can promote the up-regulation of expression of NGAL. |
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| Keywords: | Nude Mice Orthotopic Pancreatic Cancer NGAL Expression |
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