前列腺素E1对糖尿病肾病肾血流动力学的影响

目的〓〖HTK〗观察前列腺素E1（PGE1）对不同分期糖尿病肾病（diabetic nephropathy，DN）肾血流动力学的影响。〖HTW〗方法〓〖HTK〗将糖尿病肾病Ⅲ、Ⅳ、Ⅴ期患者分为2组，分别给予常规治疗（对照组）及常规＋PGE1治疗（PGE1组），应用彩色多普勒显像测定各组治疗前后肾血流动力学指标-收缩期最大血流速度（Vsmax）、舒张末期最低血流速度（Vdmin）、肾血流量（Q）及阻力指数（RI）。〖HTW〗结果〓〖HTK〗① DNⅢ期及Ⅳ期患者，PGE1组治疗15d后Vsmax、Vdmin及Q均明显增加（P＜0.01），RI明显降低（P＜0.01），治疗效果优于对照组；② DNⅤ期患者，PGE1组Vsmax、Vdmin及Q较治疗前增加（P＜0.05），RI较前降低（P＜0.05）；对照组Vsmax、Vdmin、Q及RI无明显变化（P＞0.05）； ③　各期疗效比较，Ⅲ期的治疗效果最好（P＜0.01）；两种治疗方案比较，PGE1组疗效较佳（P＜0.01）。〖HTW〗结论〓〖HTK〗PGE1对改善DN肾血流动力学具有显著疗效,且治疗越早疗效越好，Ⅴ期后疗效较差。

Effect of Prostaglandin E1 on renal hemodynamics in patients with diabetic nephropathy

Objective〓〖WTBZ〗To explore changes of renal hemodynamics in type 2 diabetes with diabetic nephropathy before and after treatment with PGE1. 〖WTHZ〗Method〓〖WTBZ〗Diabetic patients were divided into two groups: the conventional treatment group and the conventional plus PGE1 treatment group. Blood flow of the renal artery in patients with type 2 diabetes mellitus was determined by using Doppler color flow imaging before and after treatment. 〖WTHZ〗Results〓〖WTBZ〗① In patients with diabetic nephropathy(Ⅲ, Ⅳ and Ⅴ), the Vsmax, Vdmin and Q levels were significantly higher in the PGE1 group than in the conventional group（P＜0.01）, and the RI level was lower in the PGE1 group than in the conventional group（P＜0.01）. ② The response was the best in stage Ⅲ (P＜0.01）and the PGE1 group was better than the conventional group（P＜0.01）. 〖WTHZ〗Conclusion〓〖WTBZ〗PGE1 is effect in improving renal hemodynamics and the earlier the treatment acts, the better the response.