Bilirubin in coronary artery disease: Cytotoxic or protective? |
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作者姓名: | Nancy Gupta Tavankit Singh Rahul Chaudhary Sushil K Garg Gurprataap Singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin Sachin Sule |
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作者单位: | Department of Medicine,Westchester Medical Center,New York Medical College;Department of Medicine,Cleveland Clinic;Department of Medicine,Sinai Hospital of Baltimore,Johns Hopkins University;Department of Medicine,University of Minnesota;Department of Medicine,University of Pittsburgh;Einstein Healthcare Network;Government Medical College;Division of Gastroenterology and Hepatobiliary Disease,New York Medical College |
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摘 要: | Bilirubin has traditionally been considered a cytotoxic waste product.However,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative functions.These properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative stress.In fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of CAD.In this article,we review the current literature exploring the association between levels of bilirubin and risk of CAD.We conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established.
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关 键 词: | Bilirubin Cytotoxic Protective Anti-oxidant Anti-inflammatory Anti coronary artery disease Lipid peroxidation Gilbert |
收稿时间: | 2016-04-02 |
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