新生儿重症监护病房抗感染药的使用及耐药分析

目的:分析新生儿重症监护病房抗感染药的使用情况和细菌培养及耐药情况,促进抗感染药的合理使用。方法:对2005年新生儿重症监护病房抗感染药的使用和细菌培养及耐药情况进行回顾性分析。结果:我院新生儿重症监护病房主要检出菌:革兰阳性球菌以里昂葡萄球菌为主,其次为溶血葡萄球菌;革兰阴性杆菌主要是大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌和鲍曼不动杆菌。用药以头孢菌素类药物为第一位,使用频次最高的药物是头孢吡肟,亚胺培南对革兰阴性杆菌仍是最敏感药物,万古霉素对葡萄球菌是最敏感药物。结论:临床应加强抗感染药的使用管理,控制细菌耐药性的产生。

Analysis of Antibiotics Application and Drug Tolerance in Neonatal Intensive Care Units

Objective:To study antibiotics application and drug tolerance from neonatal intensive care units. Method:Sputa from NICU were cultured,bacterial strains were isolated and identified,drug tolerance was characterized in 2005,and drug application was statistically analyzed.Result:The main gram-positive bacteria were staphylococcus lug- dunensis and staphylococcus bemolyticus.The main pathogens were escherichia coli,pseudomonas neruginosa,Klebsiella pneumonia and acinetobacter baumannii.The main drugs for the treatment were cephalothin.Imipenem was the most active antibiotic against the gram-negative and norvaneomycin was the most active antibiotic against the gram-positive.Conclu- sion:In order to control the resistance of bacterial,appropriate use of antibiotics must be strengthened.