通心络对心力衰竭患者左室重构及心率震荡的影响

目的探讨通心络对慢性心力衰竭患者（CHF）左室重构及心率震荡（HRT）的影响。方法 55例老年慢性心衰患者为通心络组,对照组30例。通心络组在常规抗心衰治疗的基础上加用通心络治疗30d。在治疗前后分别测定血浆脑钠肽（BNP）、HRT指标震荡初始（TO）和震荡斜率（TS）]、左室射血分数（LVEF）、左室舒张末径（LVEDD）的变化。结果通心络组总有效率为94.55%。通心络治疗后TO、TS、LVEF、LVED、BNP较治疗前均有显著改善（P〈0.05）。结论通心络在一定程度上逆转心室重构,改善心功能。

Effects of Tongxinluo on heart rate turbulence and ventricular remodeling of patients with chronic heart failure

Objective To observe the therapeutic effect of Tongxinluo capsule on patients with chronic heart failure（CHF） and the change of heart rate turbulence.Methods 55 cases of elderly patients with CHF and 30 healthy cases（as a control group） were included in the study.The 55 patients were treated with Tongxinluo capsules,on the basis of routine therapy.The following tests were performed：B-type natriuretic peptide levels（BNP）,mean heart rate turbulence onset（TO）and turbulence slope（TS） were calculated using 24-hour Holter records.Left ventricular ejection fraction（LVEF）and left ventricular end dilatation diameter（LVEDD）were measured by ultrasonic cardiograph before and after treatment.Results There were significant differences in LVEDD,LVEF,TS,TO,and BNP before and after treatment in Tongxinluo group（P〈0.05）.The total effective rate in Tongxinluo group was significantly higher.Conclusion Tongxinluo can partially depress the ventricular remodeling of elderly patients with chronic heart failure.