247例严重药品不良反应／事件分析

目的了解严重药品不良反应／事件发生情况及特点。方法对重庆市药品不良反应监测中心2008年收集的247例严重药品不良反应／事件进行回顾性统计分析。结果抗微生物药品引起严重不良反应／事件最多；以注射剂静脉滴注最常见；严重药品不良反应／事件累及系统一器官以全身性损害最多见。结论密切关注严重药品不良反应／事件，以抗微生物药品为监测重点，提高基层医疗机构分析评价和处理严重药品不良反应／事件的能力。

Analysis of 247 Severe Adverse Drug Reaction/Event Cases

Objective To investigate the features of the severe adverse drug reaction/event（ADR/ADE）. Methods 247 severe ADR/ADE cases collected by Chongqing Center for ADR Monitoring in 2008 have been analyzed retrospectively. Results The severe ADR/ADE are mostly caused by anti-microo- rganism drugs and quite often seen in intravenous drip injections. The main type of the severe ADRJ＇ADE is systemic damage. Conclusion The severe ADR/ADE should be given attention in the clinic and anti-microorganism drugs is the topic monitoring drug. The ability of medical institutions at the grass-roots level to analyze, evaluate and cope with severe ADR/ADE should be improved.