细胞周期素D1、Ki67在鼻咽癌中的表达及意义

The Significance of the Expression of CyclinD1 and Ki67 Antigen in Nasopharyngeal Carcinoma

This study was conducted to detect the expression of cyclinD1 and Ki67 in nasopharyngeal carcinoma (NPC) and their correlation with the biological and prognosis. 56 cases of biopsy specimens of NPC which had been embedded with paraffin in 1996 in our hospital were collected and immunostained with cyclinD1 and Ki67 monoclonal antibodies by means of the streptavidin peroxides method. The patients were followed up periodically, and then their biological behaviors and prognosis were statistically analyzed. The percentage of cyclinD1 and Ki67 positive cells in the NPC specimens ranged from 0–54% and 0–31% respectively. The staining was nuclear. Of the 56 cases, 30 cases (56.6%) highly expressed cyclinD1 or Ki67 HPI and 26 cases (46.4%) lowly expressed cyclinD1, while only 16cases (28.6%) showed Ki67 HPI and 40 cases (71.4%) showed Ki67 LPI. Patients who lowly expressed cyclinD1 or highly expressed Ki67 had a higher radiosensitivity and a better prognosis. Based on these findings, cyclinD1 and Ki67 immunohistochemical staining is considered to be useful, not only as an independent factor of radiosensitivity and prognosis respectively, but also as a means of determining the optimum treatment for each individual patient NPC.