基于间质表皮转化因子/肝细胞生长因子信号通路靶向分子成像探针研究进展

间质表皮转化因子(c-Met)/肝细胞生长因子(HGF)信号通路在肿瘤发生、发展中起重要作用.分子成像可准确、无创地评价关键分子靶点在体表达水平和活化状态.基于c-M et的肿瘤靶向分子成像不仅可检测c-M et表达状态以筛选受益患者,还能监测治疗效果、评估预后,提高靶向治疗效果.本文就基于c-Met/HGF信号通路的...

Research progresses of targeted molecular imaging probes based on c-mesenchymal-epithelial transition factor/hepatocyte growth factor signal pathway

C-mesenchymal-epithelial transition factor (c-Met)/hepatocyte growth factor (HGF) signal pathway plays an important role in tumorigenesis and development. Molecular imaging can accurately and non-invasively evaluate the in vivo expression level and activation status of key molecular targets. Molecular imaging based on c-Met for tumors could not only detect the expression status of c-Met to screen beneficial patients, but also monitor therapeutic effect and evaluate prognosis, hence improving the effect of targeted therapy. The research progresses of targeted molecular imaging probes based on c-Met/HGF signaling pathway were reviewed in this article.