68Ga-DOTA-TATE与18F-FDG PET/CT对比显像用于神经内分泌肿瘤

目的 观察⁶⁸Ga-1，4，7，10-四氮杂环十二烷-1，4，7，10-四乙酸-D-苯丙氨酸1-酪氨酸3-苏氨酸8-OC（DOTA-TATE）和¹⁸F-FDG PET/CT显像用于神经内分泌肿瘤（NET）的临床价值。方法 回顾性分析39例疑似NET并先后接受⁶⁸Ga-DOTA-TATE和¹⁸F-FDG PET/CT显像患者，以组织病理学诊断结果为金标准，分析2种显像对NET的诊断效能，比较不同病理分级NET病灶的⁶⁸Ga-DOTA-TATE和¹⁸F-FDG最大标准摄取值（SUV_max）。结果 ⁶⁸Ga-DOTA-TATE PET/CT显像诊断NET的敏感度、特异度、阳性预测值（PPV）、阴性预测值（NPV）及准确率分别为96.55%（28/29）、80.00%（8/10）、93.33%（28/30）、88.89%（8/9）及92.31%（36/39），¹⁸F-FDG PET/CT显像分别为82.76%（24/29）、100%（10/10）、100%（24/24）、66.67%（10/15）及87.18%（34/39）。39例中，29例获得病理分级，包括5例G1级、16例G2级和8例G3级 NET；其中G1级、G2级及G3级NET在⁶⁸Ga-DOTA-TATE PET/CT中的SUV_max分别为28.80（15.20，44.80）、10.55（5.98，22.93）及4.70（3.90，7.50），3个级别差异具有统计学意义（H=9.06，P=0.01）；其在¹⁸F-FDG PET/CT中的SUV_max依次为3.10（2.38，5.85）、3.10（1.82，5.18）、7.10（1.70，9.93），3个级别差异无统计学意义（H=2.19，P=0.34）。结论 ⁶⁸Ga-DOTA-TATE PET/CT显像用于诊断NET及分期的价值高于¹⁸F-FDG PET/CT，且其SUV_max与病理分级相关。

68Ga-DOTA-TATE and 18F-FDG PET/CT contrast imaging for neuroendocrine tumors

Objective To explore the value of ⁶⁸Ga-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-D-Phe1-Tyr3-Thr8-OC (DOTA-TATE) and ¹⁸F-FDG PET/CT imaging for neuroendocrine tumors (NET). Methods Data of 39 patients with suspected of NET who underwent both ⁶⁸Ga-DOTA-TATE and ¹⁸F-FDG PET/CT imaging were retrospectively analyzed. Taken the histopathological results as the gold standard, the diagnostic efficacies of ⁶⁸Ga-DOTA-TATE and ¹⁸F-FDG PET/CT for NET were analyzed and compared, the maximum standard uptake value (SUV_max) were compared among different pathological grades of NET lesions. Results The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy was 96.55% (28/29), 80.00% (8/10), 93.33% (28/30), 88.89% (8/9) and 92.31% (36/39) of ⁶⁸Ga-DOTA-TATE PET/CT imaging for diagnosing NET, while of ¹⁸F-FDG PET/CT imaging was 82.76% (24/29), 100% (10/10), 100% (24/24), 66.67% (10/15) and 87.18% (34/39), respectively. Among 39 patients, pathological grading of NET was obtained in 29 patients. SUV_max of grade G1, grade G2 and grade G3 NET measured with ⁶⁸Ga-DOTA-TATE PET/CT was 28.80 (15.20, 44.80), 10.55 (5.98, 22.93) and 4.70 (3.90,7.50), respectively, and there was significant difference of SUV_max among 3 grades (H=9.06, P=0.01). Meanwhile, SUV_max of grade G1, grade G2 and grade G3 NET measured with ¹⁸F-FDG PET/CT was 3.10 (2.38, 5.85), 3.10 (1.82, 5.18) and 7.10 (1.70,9.93), respectively, and there was no significant difference of SUV_max among 3 grades (H=2.19, P=0.34). Conclusion ⁶⁸Ga-DOTA-TATE PET/CT imaging was more valuable than ¹⁸F-FDG PET/CT for diagnosing and staging of NET, and SUV_max of NET was correlated with its pathological grade.