Both poor cardiorespiratory and weak muscle fitness are related to a high concentration of oxidized low-density lipoprotein lipids |
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Authors: | Kosola J Ahotupa M Kyröläinen H Santtila M Vasankari T |
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Institution: | 1. Department of Health and Exercise, Paavo Nurmi Center, University of Turku, Turku, Finland;2. MCA Research Laboratory, Department of Physiology, and Biochemistry and Food Chemistry, University of Turku, Turku, Finland;3. Department of Biology of Physical Activity, University of Jyv?skyl?, Jyv?skyl?, Finland;4. Defence Command, Personnel Division, Finnish Defence Forces, Helsinki, Finland;5. UKK Institute for Health Promotion Research, Tampere, Finland;6. The National Institute for Health and Welfare, Helsinki, Finland |
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Abstract: | Good physical fitness is associated with favorable serum lipids. Oxidized low-density lipoprotein (ox-LDL) could be even more atherogenic than serum lipids. We studied the association of ox-LDL and serum lipids with physical fitness. Healthy young (mean age 25 years) men (n=846) underwent maximal oxygen uptake (VO(2max) ) and muscle fitness index (MFI) tests and completed a leisure-time physical activity (LTPA) questionnaire. Age (ANCOVA1), age+waist circumference+systolic blood pressure+fasting blood glucose+smoking (ANCOVA3) were used as covariates. The groups with the lowest VO(2max) , MFI and LTPA had 23%, 16% and 8% higher concentrations of ox-LDL than the groups with the highest VO(2max) (P<0.0001), MFI (P=0.022) and LTPA (P=0.039) groups, respectively. Subjects with poor fitness (low VO(2max) or low MFI) or low LTPA had elevated levels of ox-LDL/high-density lipoprotein (HDL)-cholesterol, total cholesterol, LDL-cholesterol, triglycerides and a low level of HDL-cholesterol (ANCOVA1, in all, P<0.05). Furthermore, low VO(2max) is associated with a high level of ox-LDL/HDL-cholesterol and triglycerides, and with a low level of HDL-cholesterol (ANCOVA3, in all, P<0.05). Also, subjects with low LTPA had a high ratio of ox-LDL/HDL-cholesterol (ANCOVA1, P=0.001). In conclusion, both poor fitness (both low VO(2max) and low MFI) and low LTPA are associated with a higher concentration of ox-LDL lipids and serum lipids, which may indicate a higher risk for atherosclerosis. |
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Keywords: | oxidized LDL maximal oxygen uptake muscle fitness index leisure‐time physical activity ox‐LDL and HDL‐cholesterol ratio |
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