Vergleichende ultrastrukturell-morphometrische Untersuchung zwischen der Leberparenchymzelle der Wistarratte (Rattus norvegicus) und der Wüstenratte (Meriones crassus) nach einer einmaligen CPIB (Clofibrat)-Verabreichung

Summary Male Wistar (rattus norvegicus) and desert rats (meriones crassus) were given a single dose of 200 mg/kg of clofibrate (CPIB) p.o. and liver tissue was analysed by ultrastructural morphometry. CPIB induced a biphasic reaction pattern of hepatocellular organelles both in Wistar and desert rats. In the initial phase (2–5 h) the volume share of mitochondria per hepatocyte increased in both strains. In the hepatocytes of desert rats the total number of mitochondria increased whereas the volume of the single mitochondrium remained constant. In contrast, in Wistar rats the volume of the single mitochondrium showed a threefold increase. In the initial phase the number of microbodies both in Wistar and desert rats decreased, but the single volume doubled.The smooth endoplasmic reticulum of Wistar and of desert rats showed a smaller surface per hepatocyte after CPIB application. The surface of the rough endoplasmic reticulum per hepatocyte increased in Wistar rats and decreased in desert rats. In the late phase (5–12 h) the pattern of hepatic organelles returned to normal.