血液灌流联合血液透析治疗重度药物中毒的临床研究

目的观察血液灌流联合血液透析（HPD）治疗重度药物中毒的临床疗效。方法将来我科进行急诊治疗的94例重度药物中毒患者随机分为观察组和对照组,其中对照组47例,采用常规方法治疗;观察组47例,在常规治疗的基础上采用HPD治疗,比较两组的临床疗效。结果观察组治愈率为97.9%,对照组治愈率为80.9%。观察组的治愈率显著高于对照组,差异有统计学意义（P〈0.05）;观察组患者意识恢复时间和住院时间分别为（4.5±2.7）h和（8.3±1.5）d,明显比对照组短,差异有统计学意义（P〈0.05）。结论重度药物中毒在常规治疗的基础上加用血液灌流联合血液透析治疗具有很好的临床疗效,能显著减少病死率,缩短意识恢复时间和住院时间,值得推广应用。

The study of hemoperfusion combined with hemodialysis in treatment of severe drug poisoning

Objective To observe the clinical efficacy of hemoperfusion combined with hemodialysis（HPD） in treatment of severe drug poisoning.Methods 94 patients with severe drug poisoning in our department were randomly divided into the observation group and control group,47 cases of the control group were treated by conventional therapy;47 cases of the observation group were treated by HPD therapy at the basis of conventional therapy.The clinical efficacy was compared between the two groups.Results The cure rate was 97.9% in the observation group and the control group was 80.9%.The cure rate was significantly higher than the control group,the difference was statistically significant（P 0.05） ;the time of patients＇consciousness recovery and hospital stay was（4.5 ± 2.7） h and（8.3 ± 1.5） d,they were significantly shorter compared with the control group,the difference was statistically significant（P 0.05）.Conclusion The therapy of HPD at the basis of conventional therapy in treatment of severe drug poisoning has a good clinical efficacy,it can reduce mortality and shorten the time of consciousness recovery and hospital stay significantly,and it is worth to promote.