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High-fat feeding stimulates endocrine, glucose-dependent insulinotropic polypeptide (GIP)-expressing cell hyperplasia in the duodenum of Wistar rats |
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| Authors: | D. Gniuli A. Calcagno L. Dalla Libera R. Calvani L. Leccesi M. E. Caristo R. Vettor M. Castagneto G. Ghirlanda G. Mingrone |
| Affiliation: | 1. Department of Internal Medicine and Diabetes Unit, Università Cattolica del Sacro Cuore, L.go Gemelli 8, 00168, Roma, Italy 2. Department of Medical and Surgical Sciences, Internal Medicine, University of Padua, Padua, Italy 4. Unit of Neuromuscular Biology and Pathophysiology, Department of Biomedical Sciences, CNR Institute of Neurosciences, University of Padua, Padua, Italy 5. Department of Animal House, Università Cattolica S. Cuore, Roma, Italy 3. Department of Surgery, Università Cattolica del Sacro Cuore, Roma, Italy |
| Abstract: | Aims/hypothesisIncretins are hormones released by enteroendocrine cells in response to meals, depending upon absorption of nutrients. The present study aimed to elucidate the mechanisms through which a high-fat diet (HFD) induces insulin resistance and insulin hypersecretion by focusing on the effects on enteroendocrine cells, especially those secreting glucose-dependent insulinotropic polypeptide (GIP). |
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