Toxicity after prolonged (more than four weeks) administration of intravenous colistin |
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| Authors: | Matthew E Falagas Michael Rizos Ioannis A Bliziotis Kostas Rellos Sofia K Kasiakou Argyris Michalopoulos |
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| Affiliation: | (1) Alfa Institute of Biomedical Sciences, Athens, Greece;(2) Tufts University School of Medicine, Boston, Massachusetts, USA;(3) Alfa HealthCare, Athens, Greece;(4) Intensive Care Unit, "Henry Dunant" Hospital, Athens, Greece |
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| Abstract: | Background The intravenous use of polymyxins has been considered to be associated with considerable nephrotoxicity and neurotoxicity. For this reason, the systemic administration of polymyxins had been abandoned for about 20 years in most areas of the world. However, the problem of infections due to multidrug-resistant (MDR) Gram-negative bacteria such us Pseudomonas aeruginosa and Acinetobacter baumanniii has led to the re-use of polymyxins. Our objective was to study the toxicity of prolonged intravenous administration of colistin (polymyxin E). |
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