Chiari畸形的研究进展

Chiari畸形是以小脑扁桃体下疝畸形为特，止的先天性疾患，目前较为公认的理论是起源于胚胎中胚叶轴旁的枕骨原节发育不良所敏，其诊断主要依赖于MRI。根据解剖上的异常，通常分为4型。临床分型有利于术式的选择，有Pillay、Bindal等分型，但尚无公认的分型。手术是治疗Chiari畸形的唯一有效方法，针对不同病情相位采取后颅窝减压、分流术或减压加分流手术，大部分患者的症状和体征可以得到改善。

Advancement of Chiari Malformation

Chiari malformation is a congenital malformation characterized with hindbrain hernia. It is generally accepted that it caused by underdevelopment of the occipital somite originating from the paraxial mesoderm. The diagnosis of Chiari malformation is mainly based on MRI. Chiari malformation can be classified into four types according to anatomic features. The various clinical classification, such as Pillay, Bindal, can guide the selection of surgical treatment. Surgery is the only cure-intended therapy to Chiari malformation. Majority of the patients experience improvement in their symptoms and signs after accordingly treatment, such as posterior fossa decompression and shunt.