听觉事件相关电位P300检测对两种脑梗死早期认知功能损害的临床应用分析

目的探讨听觉事件相关诱发电位（event related potential,ERP）-P300对非痴呆型脑梗死患者血管性认知功能障碍（vascular cognitive impairment,VCI）的应用价值。方法选取60例脑梗死后认知功能损害但未达到痴呆诊断标准的患者,包括皮质梗死患者30例,皮质下梗死患者30例,同时选取30例作为正常对照组患者。对所有患者进行P300检测,观察3组间P300潜伏期及波幅。结果与正常对照组潜伏期（282.41±23.87）ms和波幅（14.06±1.39）μv]相比,皮质梗死组（潜伏期（339.82±21.27）ms和波幅（10.04±1.18）μv]和皮质下梗死组潜伏期（362.66±24.34）ms和波幅（10.89±0.76）μv]P300的潜伏期差异均有统计学意义（F=52.94,P〈0.05）,且波幅差异也均有统计学意义（F=86.83,P〈0.05）;皮质下梗死组P300潜伏期与皮质梗死组相比差异也有统计学意义,但二者的波幅相比差异无统计学意义。结论脑梗死早期患者存在认知功能的受损,ERP-P300测试有利于脑梗死早期认知功能障碍的诊断,为干预治疗前移评估提供重要意义。

Clinical application of auditory event related potential P300 in cerebral infarction patients with cognition impairment

Objective To investigate the clinical application of auditory event related potential P300 in cerebral infarction non-dementia patients with vascular cognitive impairment.Methods Sixty cerebral infarction patients with cognitive decline were recruited,including 30 patients with cortical infarction（group C1）,30 patients with sub-cortical infarction（group C2）,and all patients did not match dementia diagnostic criteria.Another 30 normal patients（group C3） were also included as control group.All subjects were tested with P300,and amplitude and latency of P300 were compared among the groups.Results Compared with group C3,group C1 and C2 had longer P300 latency and lower amplitude.Prolongation of latency was more obvious in Group C2 than in Group C1,but difference of P300 amplitude did not reach statistical value.Conclusion Restults of P300 test in cerebral infarction non-dementia patients with vascular cognitive impairment are abnormal,especially in patients with sub-cortical cerebral infarction who have prolongation of P300 latency.