药物制剂技术在抑制P-糖蛋白外排作用中的应用研究近况

P-糖蛋白（P-gp）是一个ATP依赖性药物外排泵，可影响药物代谢动力学，是导致药物吸收差以及肿瘤多药耐药性产生的重要因素。综述P-gp抑制剂的作用机制和具有P-gp抑制作用的药用辅料的实验研究，探讨利用药物制剂技术抑制P-gP对药物的外排作用，促进药物体内吸收，逆转肿瘤多药耐药性。

Application of Pharmaceutical Technique to Inhibiting P-glycoprotein-mediated Drug-efflux

P-glycoprotein（P-gp）, an ATP-driven drug-efflux pump, makes a notable impact on pharmacokinetics, which leads to the poor absorption of transported substrate drugs and tumor muhidrug resistanee （MDR） development. The experimental researches on the mechanism of action of P-gp inhibitors and pharmaceutical excipients with P-gp inhibition activity were reviewed. The inhibition of P-gp-mediated drug-efflux by pharmaceutical technique was discussed to improve drug bioavailability and to reverse MDR.