高渗氯化钠对心钠素及内源性洋地黄样物质的影响

比较３０例硬膜外阻滞择期手术病人，输入７．５％ＨＳ和５％ＧＳ后血浆ＡＮＰ、ＥＤＬＳ及血流动力学的变化。输入ＨＳ后ＡＮＰ明显升高，ＥＤＬＳ短暂降低，６０ｍｉｎ完全恢复，主动脉顺应性快速增加。输入ＧＳ后ＡＮＰ有增加趋势，但无统计学意义。ＥＤＬＳ显著降低，６０ｍｉｎ时仅为基础值的。ＴＰＲ持续增加，ＣＯ和ＳＶ短暂降低，并伴有血压明显下降。揭示ＨＳ可明显刺激ＡＮＰ分泌，减缓ＥＤＬＳ变化。

Effect of Hypertonic Saline Sulution on Atrial Natriuretic Peptide and Endogenous Digitalis-like Substance in Man

he Clinical effect of hypertonic saline sulution(HS)on atrial natriuretic peptide (ANP),endogenous digital-is-like substance(EDLS)and hemodynamic data was evaluated.In HS group,ANP increased gradually up to 15%at 60 min,yet EDLS decreased transiently at 10min and recovered completely by the end of lh.However,TPRand CO were no prominent changed with the aortic compliance increased. In isotonic dextrose group,ANP in-creased without any significance,EDLS obviously decreased at 60 min,to about of the basal value. TPR in-creased but CO, SV, blood pressure declined.It suggests that HS could stimulate secretion of ANP and maintainEDLS in a higher level.