| 新水杨酸溶出度标准片的标定与评价 |
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| 引用本文： | 李杨,李连杰,黄德友,蒋登高.新水杨酸溶出度标准片的标定与评价[J].中国当代医药,2014,21(21):11-13. |
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| 作者姓名： | 李杨 李连杰 黄德友 蒋登高 |
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| 作者单位： | 李杨 (河南省食品药品检验所,郑州,450003)； 李连杰 (郑州大学化工与能源学院,郑州,450001)； 黄德友 (郑州大学化工与能源学院,郑州,450001)； 蒋登高 (郑州大学化工与能源学院,郑州,450001)； |
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| 摘 要： | 目的对新水杨酸溶出度标准片A样和B样进行标定和评价。方法分别采用篮法、桨法、小杯法对标准片进行溶出度试验，以紫外分光光度法对水杨酸的浓度进行测定。结果A样与B样的平均溶出度为26．81％、24．21％（篮法）；28．95％、26．56％（桨法）；22．50％、20．33％（小杯法）。A样与B样的RSD为1．1％、1．2％（篮法）；1．3％、2．1％（桨法）；3．7％、3．9％（小杯法）。结论两种水杨酸片均可作为标准片使用。
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| 关 键 词： | 标准片 溶出度 评价 |
Calibration and evaluation of new salicylic acid standard tablets for dissolution tester qualification |
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| Institution: | LI Yang LI Lian-jie HUANG De-you JIANG Deng-gao( 1.Henan Institute for Food and Drug Control,Zhengzhou 450003,China;2.School of Chemical Engineering and Energy, Zhengzhou University,Zhengzhou 450001,China) |
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| Abstract: | Objective To calibrate and evaluate the new salicylic acid standard tablets A and B for dissolution tester＇s qualities. Methods Dissolution tests were carried out with basket,paddle,and small glass methods.Ultraviolet-visible spectroscopy was applied to fit the concentration of salicylic acid. Results The average dissolution of A and B were 26.81%,24.21% of basket;28.95%,26.56% of paddle;22.50%,20.33% of small glass.The RSD of A and B were 1.1%, 1.2% of basket;1.3%,2.1% of paddle;3.7%,3.9% of small glass. Conclusion The new salicylic acid tablets A and B can be used as standard tablets for dissolution tester qualification. |
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| Keywords: | Standard tablets Dissolution Evaluation |
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