胰腺癌病人静息能量消耗增加与血浆细胞因子关系的研究

目的:通过检测胰腺癌病人的静息能量消耗(REE)和血浆细胞因子,探讨两者间的关系。方法:用间接能量测定法检测34例诊断为胰腺癌的病人(试验组)和同期30例腹股沟疝病人(对照组)的REE,测定血浆细胞因子(TNF-α、IL-6、IL-1),将REE和细胞因子做相关性分析。结果:试验组病人REE非常显著地高于对照组,为(1 449.03±315.47)kcal vs(1 344.67±128.52)kcal,P<0.01;呼吸商(RQ)非常显著地低于对照组,为(0.81±0.06)vs(0.88±0.08),P<0.01;细胞因子TNF-α和IL-6非常显著地高于对照组(P<0.01),而IL-1两组无显著性差异。胰腺癌病人血浆TNF-α与REE有非常显著的正相关性(P<0.01);IL-6与REE有显著相关性(P<0.05)。结论:胰腺癌病人REE显著增加,血浆细胞因子TNF-α和IL-6显著升高。胰腺癌病人REE的升高可能与细胞因子TNF-α和IL-6的升高有一定的相关性。

The measurement of resting energy expenditure of pancreatic cancer patients and its relation to cytokine

Objective: Cancer patients are often accompanied by changes in metabolism,and metabolic changes in patients with pancreatic cancer are more obvious.The study was designed to assess the metabolic changes by detecting resting energy expenditure(REE) and to explore the relationship of REE and plasma cytokine in pancreatic cancer patients.Methods: The REE of 34 patients who were diagnosed with pancreatic cancer(test group) and 30 cases of inguinal hernia patients(control group) was measured by indirect calorimetry,and plasma cytokine(TNF-α,IL-6,IL-1) were also measured.The relationships between the REE of pancreatic cancer patients and cytokine were analysed.Results: Compared with control group,the REE was significantly higher(1449.03±315.47 kcal vs 1344.67±128.52c kacl,P<0.01) and the respiratory quotient(RQ) was significantly lower(0.81 ± 0.06 vs 0.88 ± 0.08,P<0.01) in the test group.TNF-α and IL-6 were significantly higher(P<0.01) and the IL-1 was not significantly different(P>0.05) between the two groups.TNF-α or IL-6 and REE had significantly positive correlation in pancreatic cancer patients.Conclusion: In pancreatic cancer patients,the REE is significantly increased,TNF-α and IL-6 are significantly increased and the elevated REE is positively correlated with the elevated TNF-α and IL-6.