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Combined loss of CDH1 and downstream regulatory sequences drive early-onset diffuse gastric cancer and increase penetrance of hereditary diffuse gastric cancer |
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| Authors: | São José, Celina,Garcia-Pelaez,José,Ferreira,Marta,Arrieta,Oscar,André, Ana,Martins, Nelson,Solís,Samantha,Martínez-Benítez,Braulio,Ordóñez-Sánchez,María Luisa,Rodríguez-Torres,Maribel,Sommer,Anna K.,te Paske,Iris B. A. W.,Caldas,Carlos,Tischkowitz,Marc,Tusié, Maria Teresa,Hoogerbrugge, Nicoline,Demidov, German,de Voer,Richarda M.,Laurie,Steve,Oliveira,Carla |
| Affiliation: | 1.i3S–Instituto de Investigação e Inovação em Saúde, Rua Alfredo Allen, 208, 4200-135, Porto, Portugal ;2.IPATIMUP–Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal ;3.Doctoral Programme in Biomedicine, Faculty of Medicine, University of Porto, Porto, Portugal ;4.Department Computer Science Faculty of Science, University of Porto, Porto, Portugal ;5.Thoracic Oncology Unit, Department of Thoracic Oncology, Instituto Nacional de Cancerología, Mexico City, Mexico ;6.Master Programme in Molecular Medicine and Oncology, Faculty of Medicine, University of Porto, Porto, Portugal ;7.INCMNSZ/Instituto de Investigaciones Biomédicas, Unidad de Biología Molecular y Medicina Genómica Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, UNAM Mexico City, Mexico ;8.Pathology Department, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, INCMNSZ Mexico City, Mexico ;9.Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany ;10.Department of Human Genetics, Radboud University Medical Center, Radboud Institute for Molecular Life Sciences, Nijmegen, The Netherlands ;11.Cancer Research UK Cambridge Institute, University of Cambridge, Li Ka Shing Centre, Cambridge, UK ;12.Department of Oncology, University of Cambridge, Cambridge, UK ;13.Cambridge Experimental Cancer Medicine Centre (ECMC), CRUK Cambridge Centre, NIHR Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK ;14.Department of Medical Genetics, National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK ;15.Institute of Medical Genetics and Applied Genomics, Tübingen, Germany ;16.The Barcelona Institute of Science and Technology, CNAG-CRG, Centre for Genomic Regulation (CRG), Barcelona, Spain ;17.FMUP–Faculty of Medicine of the University of Porto, Porto, Portugal ; |
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