| Abstract: | In this article mechanisms of CD4 cells depletion, apoptosis, necrosis and T-cell activation, cellular immune responses to HIV infection, with emphasis on involvement of CD4 and CD8 HIV-specific cytotoxic T lymphocytes in human immunodeficiency virus infection are being discussed. Author reviews recent reports on immune restoration resulting from antiretroviral therapy, T-cell turnover within CD4 and CD8 subsets, including rapidly (activated effector and memory) and slowly (na?ve) proliferating T-cells and the influence of IL-7 on regeneration of T lymphocytes. Finally function of dendritic cells in pathomechanisms of HIV disease is summarized. |
