PTEN蛋白表达在非小细胞肺癌的临床意义研究

目的探讨PTEN蛋白在非小细胞肺癌（NSCLC）中的表达及生物学和临床意义。方法应用免疫组织化学法检测60例NSCLC组织中PTEN基因蛋白的表达，20例肺良性病变组织中PTEN基因蛋白的表达。结果PTEN蛋白在NSCLC中的总阳性表达率高于肺良性病变组织，两者比较差异有统计学意义（P〈0．01）；PTEN蛋白表达随NSCLC临床分期增加呈下降趋势，但三组之间比较差异无统计学意义（P〉0．05）；PTEN蛋白阳性表达率在NSCLC高中分化组高于低分化组，两者之间比较差异有统计学意义（P〈0．01），NSCLC无淋巴结转移组PTEN蛋白阳性表达率有淋巴结转移组，两者差异有统计学意义（P〈0．01），PTEN和nm23-H1蛋白表达与NSCLC患者年龄、性别、组织学分型、肿瘤部位及肿瘤大小均无关（P〉0．05）。结论PTEN蛋白表达与NSCLC的组织分化程度及淋巴结转移有关，NSCLC中PTEN蛋白低表达易发生淋巴结转移，检测PTEN蛋白可在一定程度上评估NSCLC的预后。

Expression and significance of PTEN in the metastasis of Non-Small Cell Lung Cancer

To explore the relationship between the expressions of PTEN and the metastasis of non - small cell lung cancer. Methotis The expression of PTEN were detected by staining in 60 cases of non - small cell lung cancer and 20 cases of benign pulmonary disease tissue. Results I The rates of positive expression of PTEN protein in NSCLC and in benign pulmonary disease tissues was a significant difference between NSCLC and benign pulmonary disease tissues （P〈0. 01）. In clinical Ⅰ , Ⅱ and Ⅲ stage of NSCLC, the rates of positive expression of PTEN protein was no significant difference among them （ P 〉 0. 05 ）. In well, moderately NSCLC and poorly-differentiated NSCLC groups, the positive rates were significant difference between them （P 〈 0. 01 ）. The difference between groups with and without lymph nodes metastasis was significant （P 〈 0. 01 ）. Conclusion The lower expressions of PTEN are related to the metastasis and pathological grade of NSCLC,