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Blocking Stemness and Metastatic Properties of Ovarian Cancer Cells by Targeting p70S6K with Dendrimer Nanovector-Based siRNA Delivery
Authors:Jing Ma  Shashwati Kala  Susan Yung  Tak Mao Chan  Yu Cao  Yifan Jiang  Xiaoxuan Liu  Suzanne Giorgio  Ling Peng  Alice S.T. Wong
Affiliation:1. School of Biological Sciences, University of Hong Kong, Pokfulam Road, Hong Kong;2. Department of Medicine, University of Hong Kong, Sassoon Road, Hong Kong;3. Aix-Marseille Université, CNRS, Centre Interdisciplinaire de Nanoscience de Marseille, UMR 7325, “Equipe Labellisée Ligue Contre le Cancer,” 13288 Marseille, France;4. State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, 210009 Nanjing, China
Abstract:
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  • Keywords:cancer stem cells  RNAi therapy  targeted therapy  dendrimer nanovector  siRNA delivery  non-viral delivery  metastasis  ovarian cancer  EPR effect  cancer nanomedicine
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