Effects of aflatoxin B1 on the growth processes of spermatogenic cell series in adult male rats

Dietary aflatoxins produce a disease state known as aflatoxicosis and disturbance of spermatogenesis is one of its serious outcomes. In this study, we evaluated the chronic effects of oral administration of aflatoxin B1 on spermatogenic cell series in adult Wistar male rats. Twenty-eight adult Wistar male rats were selected and allocated into four groups. The control group was administered sterile distilled water and the test groups; T1, T2, T3 received 0.8, 1.6, 3.2 ppm/1 cc distilled water/animal/day, respectively, for 48 days by gavage. The population of spermatogonia types A, B, and spermatozoa were significantly decreased in all test groups (p?p?1 can decrease spermatogenic cells in a dose-dependent mode.