Responses of olfactory bulb neurones to the dipeptide carnosine |
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Authors: | N. K. MacLeod M.D. D. W. Straughan |
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Affiliation: | (1) Department of Pharmacology, The School of Pharmacy, 29/39 Brunswick Square, WC1N 1AX London, Great Britain |
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Abstract: | Summary Carnosine has been applied by microiontophoresis to identified neurones in the olfactory bulb of the rat from solutions of different pH. Although mainly without effect when compared with conventional excitatory and inhibitory amino acids, the dipeptide tended to be depressive when ejected as a cation and excitant when ejected as an anion. The results obtained are not in favour of this substance being an excitatory transmitter in the primary olfactory pathway. |
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Keywords: | Olfactory bulb Microiontophoresis Carnosine Amino acids |
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