Fecal Adnab-9 binding as a risk marker for colorectal neoplasia |
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Authors: | Yuan Mei Xhang XiaoPing Leu YiaLi Xu Yi Ullah Nadeem Lawson Michael Tobi Martin |
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Institution: | Institute of Basic Medical Science, General Hospital of PLA, Beijing, China. |
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Abstract: | Adnab-9 binding in colonic tissue and effluent has been associated with an increased risk for colorectal neoplasia. We investigated if fecal binding by Adnab-9 may be used as a marker for colorectal neoplasia. A fecal-Adnab-9 ELISA was performed on samples of 249 patients and colonoscopic pathology results correlated. Fecal Adnab-9 binding was seen in 63% of patients with colorectal neoplasia (59% with colorectal cancer and 83% with adenoma), 33% with inflammatory bowel disease, 0% with hyperplastic polyps and 10% of controls. We conclude that fecal Adnab-9 binding is a promising risk marker for colorectal neoplasia. |
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Keywords: | Colonic polyps Colorectal neoplasia Monoclonal antibodies Adnab-9 |
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