| 大鼠阿霉素肾病的病理学观察 |
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| 引用本文： | 许涛,吕磊,钱琛,王迎新.大鼠阿霉素肾病的病理学观察[J].中国临床药理学与治疗学,2001,6(1):43-45. |
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| 作者姓名： | 许涛 吕磊 钱琛 王迎新 |
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| 作者单位： | 1. 安徽中医学院病理教研室，合肥 230061
2. 安徽省卫生干部进修学校，合肥 230038 |
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| 摘 要： | 目的建立大鼠肾病综合征模型并观察其临床表现及生理、病理改变。方法阿霉素组鼠于试验开始d1和d15分别尾静脉内注射阿霉素5mg
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| 关 键 词： | 大鼠 阿霉素 肾病 疾病动物模型 |
| 修稿时间： | 2001年1月25日 |
Pathological observation
of adriamycin nephropathy in rats |
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| XU Tao,LV Lei,QIAN Chen,WANG Ying-xin.Pathological observation
of adriamycin nephropathy in rats[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2001,6(1):43-45. |
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| Authors: | XU Tao LV Lei QIAN Chen WANG Ying-xin |
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| Institution: | XU Tao LV Lei QIAN Chen WANG Ying_Xin1 |
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| Abstract: | Aim To establish the model of adriamycin- induced nephritic syndrome in rats and its pathological change was observed. Methods The model of nephritic syndrome in rats was established by intravenous injection of adriamycin in the dose of 5mg · kg-1 and 3 mg · kg-1 respectively at the first day and 15 th day. The amount of urine protein was measured at the 1、2、3、4、6、8 and 12 th week and the serum biochemical pa rameters of TG, TCH, BUN, Cr, TP and ALB were detected at the 6 th and 12 th week. Results The urine protein and the serum biochemic parameters were increased significantly, except the TP and ALB, which were decreased. Pathological changes at the sixth week was similar to minimal changes in glomerulonephritis, and at the 12 th week, sclerosis of glomeruli of kidney could be found. Conclusion After first injection, the changes of kidney were like those in minimal change glomerulonephritis of human being. But after the second injection. The kidney had the changes of focal segmental glomeralosclerosis. |
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| Keywords: | rats adriamycin nephropathy model of animal |
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