Morphological changes of interventricular septum in long-term follow-up cases]

In patients who could be followed by echocardiography for a long period, the clinical significance of sigmoid septum and basal septal hypertrophy including long-term changes was investigated in patients with hypertension. The subjects were 66 patients (24 males and 42 females, mean age: 53 +/- 12 years old) who underwent repeated echocardiography, and the initial examination and observation after long-term follow-up (mean duration of follow-up: 10.8 +/- 1.4 years) were compared. Sigmoid septum was more advanced at the time of initial examination in the hypertensive group than in the normotensive group, but it was similarly advanced after the long-term follow-up in both groups. There was no significant difference in basal septal hypertrophy between the hypertensive and normotensive groups at the time of initial examination, but significant increases in thickening were observed in the hypertensive group after the long-term follow-up. The above findings suggested that morphological changes in the interventricular septum reflect the severity of arteriosclerosis that is expected to be more advanced in hypertensive patients than in normotensive patients.