炎痛克贴剂对实验性大鼠输卵管炎症阻塞的对抗作用

目的:探讨炎痛克贴剂对实验性大鼠输卵管炎症阻塞的对抗作用。方法:以大鼠棉球肉芽肿实验观察炎痛克贴剂的抗炎作用;以苯酚糊剂造实验性大鼠输卵管炎性阻塞模型,观察炎痛克贴剂的对抗作用及对血液流变学的影响。结果:本药有明显的抗炎作用(P<0.01),对炎性阻塞模型能明显减轻病变,并使血液流变学指标得到改善。结论:本药能较好地通过透皮吸收对抗妇科及腹部炎症,为开发新药提供了药理学依据。

The opponens action of Yantongke(YTK) sticking on the salpingitic block of the experimental rat

Objective: The action of YTK was disscused,such as the antiinflammation action and the opponens action on the salpingitic block of the experimental rats and the effect on hemorheology.Methods: The action of antiinflammation of YTK was observed through granulomas of rats caused by cotton,the models of the salpingitic block of rats caused by potassium paste were made to observe the opponens action of YTK and the effect on hemorheology.Results: This drug had antiinflammation action obviously(P<0.01): deducing the lesion of the salpingitic block model remarkably,and improving the index of hemorheology.Conclusion: Above-mentioned results show this medicine had effective actions to oppose gynecologic and abdomen inflammation through transdermal absorption,offering pharmacology for developing a new drug.