| 针刺正常大鼠肺组织SAGE标签数据库的基因分类研究 |
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| 引用本文： | 尹磊淼,徐玉东,王宇,刘艳艳,张庆华,杨永清.针刺正常大鼠肺组织SAGE标签数据库的基因分类研究[J].上海针灸杂志,2010,29(5):315-317. |
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| 作者姓名： | 尹磊淼 徐玉东 王宇 刘艳艳 张庆华 杨永清 |
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| 作者单位： | 1. 上海中医药大学,上海,201203;上海市针灸经络研究所,上海,200030
2. 生物芯片上海国家工程研究中心,上海,201203 |
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| 基金项目： | 国家自然科学基金，上海市卫生局青年基金，上海高校选拔培养优秀青年教师科研专项基金，上海市教委科研创新项目 |
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| 摘 要： | 目的阐释生理状态下针刺对大鼠肺组织基因表达谱的影响。方法利用正常组和针刺组的大鼠肺组织基因表达连续分析（SAGE）标签数据库,对差异表达标签进行基因系统分类和分析。结果正常组和针刺组相比共获得144个差异表达标签,分属于细胞生物合成过程、细胞脂类代谢过程、物质转运等6个DAVID基因分类。结论生理状态下针刺基础背景作用是一个包含蛋白、酶、RNA、脂类等生物大分子合成和代谢以及物质转运的生物过程。
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| 关 键 词： | 针刺 基因表达谱 大鼠 |
Study of Lung Gene Classification Based on the SAGEmap Database in Acupunctured Normal Rats |
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| YIN Lei-miao,XU Yu-dong,WANG Yu,LIU Yan-yan,ZHANG Qing-hua,YANG Yong-qing.Study of Lung Gene Classification Based on the SAGEmap Database in Acupunctured Normal Rats[J].Shanghai Journal of Acupuncture and Moxibustion,2010,29(5):315-317. |
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| Authors: | YIN Lei-miao XU Yu-dong WANG Yu LIU Yan-yan ZHANG Qing-hua YANG Yong-qing |
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| Institution: | YIN Lei-miao1,2,XU Yu-dong1,WANG Yu1,LIU Yan-yan1,ZHANG Qing-hua3,YANG Yong-qing1,2. 1.Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China,2.Shanghai Research Institute of Acupuncture , Meridian,Shanghai 200030,3.Shanghai National Biochip Engineering Research Center |
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| Abstract: | Objective To explain the effect of acupuncture on rat lung gene expression profiles in physiological status. Methods Systematic gene classification and analysis of different expression tags were made using the (SAGE) tag database of serial analysis of rat lung gene expression in normal and acupuncture groups. Results A total of 144 difference expression tags were obtained as the normal group was compared with the acupuncture group. They fell into six DAVID gene categories such as cellular biosynthesis, cell... |
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| Keywords: | Acupuncture Gene expression profiles Rat |
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