急性期川崎病患儿血清IL-21变化探讨

目的：探讨急性川崎病患儿血清中IL-21的变化。方法选取60例川崎病患儿，使用双抗体夹心酶联免疫吸附试验方法检测血清中的IL-21水平。选取40例正常同年龄小儿对照。结果急性期川崎病患儿血清IL-21水平明显高于对照组，差异有统计学意义（P＜0.05）；且伴有冠状动脉病变的川崎病患儿IL-21水平较无冠状动脉病变患儿增高,差异有统计学意义（P＜0.05）；急性期川崎病患儿血清IL-21水平与冠状动脉扩张程度存在明显正相关（r=0.497，P＜0.05）。结论 IL-21可能参与了川崎病的发生发展，在川崎病冠状动脉变化过程中起到重要作用，可作为预测川崎病患儿病情严重程度及是否易并发冠状动脉病变的一项指标。

The significance of the level of serum IL-21 level in children with acute Kawasaki disease

Objective To probe the serum IL-21 level in children with acute Kawasaki disease. Methods The level of serum IL-21 from 60 children with acute KD and that in 40 normal children were detected by enzyme-linked immune sorbent assay （ELISA） respectively. Results The level of serum IL-21 in acute KD patients was obviously higher than that in healthy control （P〈0.05）. In addition,the level of serum IL-21 level in acute KD patients showed positive correlation with the degree of coronary artery dilatation （r=0.497,P〈0.05）. Conclusion The evident increase of serum IL-21 level in acute KD patients has positive correlation with the degree of coronary artery dilatation,which suggests that IL-21 may play a activity in KD. It takes important part in the development of KD,and is an evident mark to predict the complication occurence of CAL in acute KD patients.