血清胱抑素C、同型半胱氨酸、超敏C反应蛋白与不同类型脑梗死的相关性分析

目的：探讨血清胱抑素C（cystatin C,Cys C）、同型半胱氨酸（homocysteine,Hcy）、超敏C反应蛋白（high sensitivity C reactive protein,hs CRP）水平与不同类型急性脑梗死的关系。方法：选择神经内科收治的100例急性脑梗死患者为观察组,并按照TOAST分型标准进行病因分型;选择80例非脑卒中病例为对照组,分别测定和比较两组患者血清Cys C、Hcy以及hs CRP的水平。结果：脑梗死组患者血清Cys C、Hcy、hs CRP水平高于对照组（P〈0.05）,经Logistic回归分析三者均为脑梗死的危险因素（OR值分别为1.989、2.013、1.601）;观察组中大动脉粥样硬化型（LAA）、小动脉闭塞型（SAA）患者血清Cys C、Hcy、hs CRP水平均高于对照组（P〈0.05）,其中以LAA型增高显著（P〈0.01）。结论：血清Cys C、Hcy和hs CRP水平升高均与脑梗死密切相关,可能是脑梗死的危险因素,但不同亚型脑梗死可能有不同病因。

An Analysis of the Correlation of Plasma CysC,Hcy and hs-CRP with Different Types of Cerebral Infarction

Objective ：To investigate the relationship of serum cystatin C （CysC） ,homocysteine （Hcy）and high sen_sitivity C reactive protein （hs-CRP） with different types of Cerebral Infarction .Methods ：100 cases of acute cerebral in_farction hospitalized in our department of Neurology were selected to be the cerebral infarction group ,with etiological typ_ing performed by TOAST criteria .80 cases of non -cerebrovascular disease were enrolled as a control group .The con_centration of CysC ,Hcy and hs-CRP in the blood serum of the two groups was determined and compared to find if there is any difference between the two groups .ResuIts ：The level of CysC ,Hcy and hs-CRP in the cerebral infarction group was significantly higher than that in the control group（ P＆lt;0 .05） ,with Logistic regression analysis revealing that CysC , Hcy and hs-CRP were the risk factors for cerebral infarction （OR：1 .989 ,2 .013 and 1 .601） .The level of serum CysC , Hcy and hs -CRP of LAA and SAA patients in the cerebral infarction group was higher than that in the control group （ P〈0 .05） ,most significantly higher in LAA patients（ P〈0 .01） .Conclusion ：The level of CysC ,Hcy and hs-CRP ,the possible risk factors ,were closely related to acute cerebral infarction .There may be various etiological factors for differ_ent subtypes of cerebral infarction ,however .