固本消疣汤内服结合干扰素术区皮下注射对肛门尖锐湿疣术后复发的临床疗效观察

目的:评价固本消疣汤内服结合干扰素术区皮下注射治疗肛门尖锐湿疣术后患者的临床疗效及复发情况。方法:将符合纳入标准的80例行肛门尖锐湿疣经高频电刀切除术彻底清除肉眼可见疣体后的患者随机分为治疗组和对照组各40例,治疗组术后口服固本消疣汤结合干扰素术区皮下注射治疗,对照组术后仅采用干扰素术区皮下注射治疗。治疗期为术后1个月,观察期为术后3个月,对3个月内复发率,复发时间进行研究对比。结果:观察期结束后,治疗组患者复发率为7.5%,对照组患者复发率为27.5%,治疗组明显优于对照组,差异有统计学意义(P0.05)。治疗组患者平均复发时间(78±18.19)d,对照组平均复发时间(43±17.61)d。2组复发时间比较,差异有统计学意义(t=-3.034,P0.05)。结论:通过本次研究表明,固本消疣汤内服结合干扰素术区皮下注射治疗肛门尖锐湿疣术后患者,复发率、复发时间均优于仅使用干扰素术区皮下注射治疗的患者,其用于临床有效,复发率低,值得推广。

Observation on Clinical Effect of Orally-taking Guben Xiaoyou Decoction Combined with Interferon Hypodermic Injection in Operative Region for Patients with Postoperative Recurrence of Anus Condyloma Acuminata

Objective:To assess the clinical effect and recurrence of Guben Xiaoyou decoction combined with interferon hypodermic injection in operative region for postoperative patients with anus condyloma acuminiata (ACA).Methods:A total of 80 ACA patients after electrosurgical excision were randomly divided into treatment group using Guben Xiaoyou decoction combined with interferon hypodermic injection in operative region and control group using interferon hypodermic injection in operative region only.The treatment period lasted for one month,and the observation period lasted for three months after operation.The rate and time of recurrence within 3 months were compared finally.Results:After the observation,the recurrence rate of the treatment group (7.5％) was obviously superior to that of the control group (27.5 ％),which was statically significant (P ＜ 0.05);the average recurrence rate time of the treatment group and the control group was 78 ± 18.19 days and 43 ± 17.61 days respectively,which was statically significant (t =-3.034,P ＜ 0.05).Conclusion:Comparing with interferon hypodermic injection in operative region only,the study showed that the integrative therapy of orally-taking Guben Xiaoyou decoction combined with interferon hypodermic injection in operative region was superior in both the rate and time of recurrence.It is worth being popularized for its clinical effectiveness and lower recurrence.