基于益气法治疗癌因性疲乏的Meta分析

目的:明确益气中药联合化疗治疗癌因性疲乏的临床疗效,为临床提供有力的循证医学证据。方法:首先,从中国知网数据库、万方数据库、维普数据库、Pubmed等网页中检索2014年1月~2017年3月之间采用益气中药联合化疗对比单纯化疗治疗癌因性疲乏的随机对照试验文献,并对文献进行阅读筛选;其次,运用Rev Man5.3软件对纳入的文献进行质量评价,相关指标和基本信息的提取。结果:通过反复阅读文献摘要甚至全文,最终获得符合研究的文献共11篇,共提取研究对象共847例,其中治疗组439例(化疗+益气中药),对照组408例(单纯化疗)。Meta分析结果提示益气中药联合化疗组和单纯化疗组在癌因性疲乏程度的总缓解率方面有显著统计学差异OR=3.55,95%CI(2.60,4.84),P0.00001];在生活质量改善方面:OR=2.42,95%CI(0.90,5.02),P0.0001];近期疗效方面:OR=2.80,95%CI(1.58,4.96),P0.0001];不良反应方面:OR=0.35,95%CI(0.26,0.49),P0.00001]。结论:益气中药联合化疗较单纯化疗能显著改善癌因性疲乏患者的临床症状,从而提高患者生活质量。

Meta Analysis of Treatting Cancer Related Fatigue with the Traditional Chinese Medicine of Supplementing Qi Combined with Chemotherapy

Objective:Clearring the method of treating cancer related fatigue with traditional Chinese medicine of Supplementing Qi combined with chemotherapy is more exact than chemotherapy in curative effect.Methods:First,Searching literature from CNKI,Wanfang database,VIP database,Master's doctoral thesis,Pubmed database which used the method of treating cancer related fatigue with traditional Chinese medicine of Supplementing Qi combined with chemotherapy contrast chemotherapy alone and use the randomized controlled trials.Secondly,using the RevMan5.3 software to evaluate the quality of the collected literature and extracting relevant data.Results:A total of 11 articles were adopted,there are a total of 847 cases,and 439 cases in the treatment group,Control group of 408 cases.The results of the meta analysis showed that There was significant statistical difference between Chinese medicine and chemotherapy inthe treatment of cancer-related fatigue,OR =3.55,95％ CI (2.60,4.84),P ＜ 0.00001];In terms of quality oflife:OR=2.42,95％ CI (0.90,5.02),P＜0.0001];Recent efficacy:OR=2.80,95％ CI (1.58,4.96),P＜ 0.0001];Adverse reactions:OR=0.35,95％ CI (0.26,0.49),P＜0.00001].Conclusion:Chinese medicine combined with chemotherapy can significantly improve the clinical symptoms of patients with cancer-related fatigue,thus improving the quality of life of patients.