Molecular analysis of the destruction of articular joint tissues by Raman spectroscopy |
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| Authors: | Paula Casal-Beiroa Pío González Francisco J Blanco |
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| Institution: | 1. Unidad de Medicina Regenerativa, Grupo de Investigación en Reumatología, Instituto de Investigación Biomédica de A Coru?a (INIBIC) ., A Coru?a, Spain;2. Centro de Investigaciones Científicas Avanzadas (CICA), Universidad de A Coru?a (UDC) ,A Coru?a, Spain;3. New Materials Group, Department of Applied Physics, University of Vigo , Vigo, Spain |
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| Abstract: | ABSTRACT Introduction Osteoarthritis (OA) is a highly heterogenous disease influenced by different molecular, anatomic, and physiologic imbalances. Some of the bottlenecks for enhanced diagnosis and therapeutic assessment are the lack of validated biomarkers and early diagnosis tools. In this narrative review, we analyze the potential of Raman spectroscopy (RS) as a label-free optical tool for the characterization of articular joint tissues and its application as a diagnosis tool for OA. |
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| Keywords: | Optical biomarkers osteoarthritis Raman spectroscopy diagnosis joint tissues |
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