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Assessment of thiol/disulphide homoeostasis and ischaemia-modified albumin and their relationship with disease severity in children with chronic urticaria
Authors:Songul Akdag  Nazli Ercan  Ilknur Bostanci  Salim Neselioglu
Affiliation:1. Pediatrics, Dr. Sami Ulus Gynecology Obstetrics and Child Health and Diseases Training and Research Hospital, University of Health Sciences, Ankara, Turkey;2. Pediatric Allergy and Immunology, Dr. Sami Ulus Gynecology Obstetrics and Child Health and Diseases Training and Research Hospital, University of Health Sciences, Ankara, Turkey;3. Department of Biochemistry, Yildirim Beyazit University, Faculty of Medicine, Ankara, Turkey "ORCIDhttps://orcid.org/0000-0002-0974-5717
Abstract:Abstract

Background

The pathogenesis chronic urticaria (CU) hasn't been fully understood. In recent years, it has been shown that thiol-disulphide homoeostasis, as an antioxidant system, plays important roles in both healthy individuals and various diseases. In different ischaemia-reperfusion states, high oxidative stress causes ischaemia-modified albumin (IMA) generation.
Keywords:Children  ischaemia-modified albumin  chronic urticarial  oxidative stress  thiol-disulphide homeostasis  urticaria activity score
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