Intravital imaging of megakaryocytes |
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| Authors: | David Stegner Katrin G. Heinze |
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| Affiliation: | 1. Institute of Experimental Biomedicine, University Hospital Würzburg , Würzburg, Germany stegner@virchow.uni-wuerzburg.de katrin.heinze@virchow.uni-wuerzburg.de!["ORCID]("//:0" "\"ORCID") https://orcid.org/0000-0003-1059-9865;3. Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg , Würzburg, Germany https://orcid.org/0000-0003-2372-6800 |
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| Abstract: | Abstract The dynamics of platelet formation could only be investigated since the development of two-photon microscopy in combination with suitable fluorescent labeling strategies. In this review paper, we give an overview of recent advances in fluorescence imaging of the bone marrow that have contributed to our understanding of platelet biogenesis during the last decade. We make a brief survey through the perspectives and limitations of today’s intravital imaging, but also discuss complementary methods that may help to piece together the puzzle of megakaryopoiesis and platelet formation. |
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| Keywords: | Intravital imaging megakaryocytes thrombopoiesis two-photon microscopy |
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!["ORCID]({"type":"image","src":"/templates/jsp/images/orcid.png"} "\"ORCID")
https://orcid.org/0000-0003-1059-9865;3. Rudolf Virchow Center for Experimental Biomedicine, University of Würzburg , Würzburg, Germany