Current and emerging treatments for neonatal sepsis |
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Authors: | Federico Carbone Fabrizio Montecucco |
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Affiliation: | 1. First Clinic of Internal Medicine Department of Internal Medicine, University of Genoa , Genoa, Italy;2. IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network , Genoa, Italy;3. IRCCS Ospedale Policlinico San Martino Genoa - Italian Cardiovascular Network , Genoa, Italy;4. First Clinic of Internal Medicine, Department of Internal Medicine and Centre of Excellence for Biomedical Research (CEBR), University of Genoa , Genoa, Italy https://orcid.org/0000-0003-0823-8729 |
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Abstract: | ABSTRACT Introduction Mortality due to sepsis is still prevalent, peaking at extreme ages of life including infancy. Despite many efforts, the peculiarity of the infant immune system has limited further advances in its treatment. Indeed, neonates experience a dramatic physiological transition from immune tolerance to the maternal antigens to functional maturity. Such a transition is extremely dynamic, as is the pathophysiology of infant sepsis, which is dependent on many infant, maternal, and environmental factors. |
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Keywords: | Infant sepsis immunomodulation lactoferrin zinc probiotics |
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