卡泊芬净治疗恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染的临床观察

目的分析卡泊芬净治疗恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染临床效果及安全性。方法选取2009年3月至2012年5月收治恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染患者50例,采用随机数字表法分为两性霉素B组和卡泊芬净组,分别采用两性霉素B和卡泊芬净静脉滴注治疗;比较两组患者临床治疗总有效率及不良反应发生率等。结果两性霉素B组总有效率(72.0%)与卡泊芬净组患者(76.0%)比较无显著差异(P>0.05);两性霉素B组不良反应发生率(36.0%)明显高于卡泊芬净组(P<0.05)。结论卡泊芬净早期治疗恶性血液病化疗后中性粒细胞缺乏合并深部真菌感染临床效果满意,且无严重不良反应。

Clinical study on neutropenia complicated with deep fungal infection in patients with malignant hematological diseases after chemotherapy.

Objective To analyze the therapeutic effects and safety of caspofungin in treatment of patients with malignant hematological diseases complicated with neutropenia and deep fungal infection after chemotherapy. Methods Fifty patients with malignant hematological disea- ses complicated with neutropenia and deep fungal infection after chemotherapy during the period of March 2009 to May 2012 in this hospital were selected and randomly divided into two groups, 25 patients in amphotericin B group treated with amphotericin B and 25 patients in caspofungin group treated with caspofungin; and the total efficacy and adverse effects were compared between these 2 groups. Results There was no signifi- cant difference in total efficacy between amphotericin B group （72.0%）and caspofungin group （76.0%） （ P 〉 0.05 ）. The incidence rate of ad- verse reactions in caspofungin group （0%）was significantly lower than that of amphotericin B group （36.0%） （ P 〉 0.05 ）. Conclusion Caspo- fungin in treatment of deep fungal infection complicated with neutropenia in patients with malignant hematological diseases after chemotherapy has perfect therapeutic efficacy and few adverse reactions.