超量阿托伐他汀对不稳定型心绞痛患者血管内皮功能的影响

目的：探讨短期大剂量阿托伐他汀对不稳定型心绞痛（UAP）患者早期血管内皮功能改善的疗效。方法：72例UAP Ⅲ级患者被分为大剂量组和常规量组，于人院后给予口服不同剂量的阿托伐他汀2周，分别测定治疗前后的血脂（TC、TG、LDL—C、HDL—C）、反应性充血引起的肱动脉舒张内径变化率（ΔD％）。并于2周内观察各组发生心脏意外事件的情况。结果：大剂量组服药2周后血脂TC、TG、LDL-C水平显著下降（P〈0．05），肱动脉AD％明显增高（P〈0．01），心脏意外事件发生率为62．86％，常规量组血脂指标均无明显变化，心脏意外事件发生率为83．78％，较之大剂量组显著增加（P〈0．05）。结论：对于不稳定型心绞痛Ⅲ级患者短期大剂量阿托伐他汀治疗可改善血管内皮功能、降低心脏意外事件发生率，改善预后。

Influence of large dose atorvastatin on vascular endothelial function in patients with unstable angina pectoris early

Objective： To investigate the effects of large dose atorvastatin in short time on vascular endothelial function in patients with unstable angina pectoris （UAP） early. Methods： A total of 72 patients with UAP grade Ⅲ were randomly divided into large dose group and regular dose group and took different dose atorvastatin for two weeks. Lipid （TC, TG, LDL-C, HDL-C） level, change rate of brachial artery relaxant inner diameter reacted to congestion （ΔD%） were measured before and after treatment of atrovastatin, and the cardiac accidents were observed within two weeks. Results： After 2 weeks of taking atorvastatin in large dose group, the lipid （TC, TQ LDL-C） levels decreased （P〈0.05）, ΔD% of relaxant brachial artery markedly increased （P〈0.01）, the incidence of cardiac accidents was 62.86%. But in regular dose group there were not significant changed of lipids （TC, TQ LDL-C, HDL-C） levels, the incidence of cardiac accidents was 83.78%, it was more than that of large dose group （P〈0.05）. Conclusion： Effects of large dose atorvastatin treatment on vascular endothelial function is better than that of regular dose group and decreasing incidence of cardiac accidents.