survivin、Cyclin D1 蛋白及抑癌基因PTEN在子宫颈癌中的表达及其相关性研究

目的：探讨凋亡抑制蛋白survivin、抑癌基因PTEN、细胞周期蛋白Cyclin D1在子宫颈癌中的表达及其临床意义。方法：应用免疫组化SP法，检测survivin、PTEN及Cyclin D1在52例子宫颈癌（鳞癌46例、腺癌6例）及10例正常子宫颈组织中的表达。结果：与正常子宫颈组织比较，survivin与Cylin D1表达率明显增高，而PTEN的表达率明显降低，差异有统计学意义（P〈0.05）。survivin和Cyclin D1蛋白的表达与子宫颈癌的病理分级呈正相关（r值分别为0．57和0．67，P〈0.05）。而PTEN的表达病理分级呈负相关（r=0．61，P〈0.05）。结论：survivin，Cyclin D1对子宫颈癌的发生、发展起着促进作用，而PTEN的表达对子宫颈癌的进展起着阻碍作用。

Survivin, tumor suppressor PTEN, Cyclin D1 proteins expression and dependability in cancer of the cervix

Objective To study the expression of survivin,PTEN and Cyclin D1 proteins in cervical cancer.Methods Immunohistochemistry method was used to examine the protein expression of survivin,PTEN and Cyclin D1 in 52 cases of the cervix cancer(46 cases of cervical squamous carcinoma and 6 of cervical adenocarcinomas) and 10 normal cervical tissues. Results There was a significant statistic difference in the positive results of survivin and Cyclin D1 protein and PTEN between normal cervical tissues and cervical cancer(P<0.05).Survivin and Cyclin D1 were up-regulated in cervical cancer and had a positive correlation with the clinical staging.PTEN was down-regulated in cervical cancer and had a negative correlation with the clinical staging.Conclusion Survivin and Cyclin D1 can improve the development and progression of cervical cancer.PTEN can inhibit the development of cervical cancer.