超声光散射乳腺成像诊断乳腺癌假阳性率分析

目的：超声光散射乳腺成像系统（OPTIMUS）是多模式的可以进行早期乳腺癌普查、诊断及疗效检测的系统。本研究回顾经手术后病理证实的160 例乳腺肿瘤的OPTIMUS系统表现与病理结果对比分析，评价OPTIMUS系统的临床应用价值。方法：对160 例乳腺肿瘤患者进行OPTIMUS系统检查，将检查结果及手术病理进行总结，并与相应的钼靶及超声结果进行对比，用卡方检验分析结果有无统计学差异。结果：OPTIMUS系统诊断良性病变42例，恶性病变118 例。术后病理诊断良性病变60例，恶性病变100 例。假阳性率为30.0% ，假阴性率为0。OPTIMUS系统诊断乳腺癌准确性88.8%（142/160），敏感性100.0%（100/100）；相应超声及钼靶检测准确性分别为87.6% 和87.1% ，无统计学差异；敏感性分别为86.8% 和87.1% ，与OPTIMUS系统有统计学差异。结论：OPTIMUS系统对诊断乳腺恶性肿瘤的准确性及敏感性较高，是提高乳腺良恶性病变鉴别诊断的有效方法。

False Positive Diagnosis of Breast Cancer by Diffused Optical Tomography with Ultrasound

Objective: To evaluate the value of OPTIMUS system in the diagnosis of breast disease. Methods:OPTI-MUS system was applied to160 breast tumor patients. All patients had received surgical treatment and had a definite path -ological diagnosis. OPTIMUS system was evaluated as a diagnostic tool for breast tumors in this study. Results: There were42cases of patients diagnosed with benign breast disease and 118 cases diagnosed with breast cancer by OPTIMUS system. Pathology confirmed 60cases of benign disease and 100 cases of breast cancer. The false positive rate of breast cancer was30% (18/60). False negative rate of breast cancer was 0 (0/100 ). OPTIMUS system had an accuracy of 88.8%, while ultrasonography and mammography had an accuracy of 87.6% and 87.1%, respectively. The sensitivity of OPTIMUS system, ultrasonography and mammography were 100 .0%,86.8% and 87.1%, respectively, and showed significant differ-ences. Conclusion:OPTIMUS system is a non-invasive and highly effective diagnostic tool for breast disease and it could be used as an assistant diagnostic tool for breast tumor.