邻氯-N,N-二乙基苯甲酰胺的合成及药效

目的：合成新驱避剂，并测定其药效。方法：自行合成，并以人体和小白鼠为试验对象，在实验室和野外进行防蚊效果试验。结果：ＫＩＫ合成工艺简便，其１０％酊剂在实验室内涂于人体皮肤防止白纹伊蚊叮咬，１００％保护率为４ｈ，小白鼠为５ｈ；野外１５％酊剂涂于人体皮肤防止蚊虫叮咬，１００％保护率为６ｈ，与ＤＥＴＡ无明显差异。结论：该化合物合成简便，成本较低，防蚊效果较好。

Synthesis of o-Chloride-N,N-Diethylbenzoylamide and its Efficacy

Objective: To synthesize a new type of repellant and determine its efficacy. Method: To synthesize the compound by ourself and make efficacy test against mosquitoes with man body and small white mouse as a object of test in laboratary and field. Result: Synthesis technology of the compound is convenient. Coating 10% alcohol preparation of the compound on man or small mouse skin, the time keeping from Aedes albopictus were 4 hrs and 5 hrs respectiely. In the field test, coating 15% alcohol preparation of the compound on man skin, the time keeping from mosquitoes was 6 hrs,it had no notable difference between the compound and DETA. Conclusion: This compound has many advantages that the technology is convenient, the cost is low, the efficacy is quite good. It is worth of further developing and application.