犬下颌复合器官同种异体移植的实验研究

目的探索利用同种异体器官和组织移植方法修复下颌区大型缺损的可能性。方法１４只犬进行了三种类型的下颌复合器官同种异体原位移植。第一类型移植模型包括半侧下颌骨及其附着的牙齿、肌肉、皮肤和粘膜；第二类型在第一类型的基础上去除口腔粘膜；第三类型则去除粘膜和牙冠，用环孢霉素和甲基泼尼松配合抑制排斥反应。结果下颌区复合器官具有有效的循环回路，进行血管化的移植是可行的，２只存活时间最长的动物均为第三类型的移植模型，分别为术后６７天和７６天，环孢霉素可以有效地抑制排斥反应，延长移植物存活时间。结论同种异体下颌复合器官移植能最大限度地恢复下颌区大型缺损所造成畸形的容貌和丧失的功能。

Mandibular compound organs allotransplantion in canines

Objective To evaluate the feasibility of transplanting composite madibular allogratts to reconstruct large mandibular defects. Methods Three composite mandibular transplantation models were designed. The first consisted of hemimandible with the attached teeth, muscles and skin, and oral mucosa. The second was transplanted as the first excluding oral mucosa and some teeth, and the third excluding oral mucosa and all dental crowns. Fourteen transplanting operations were done in canines. Cyclosporine A and methylprednisone were given for immunosuppression. Results It was confirmed that the composite mandibular organs had an effective and closed return circuit. Transplantation of vascularized mandibular compound organs allografts was feasible. Two longest survivors. 67 and 76 days, were in the third model. Cyclosporine A was successful in suppressing rejection in composite allograft transplant and prolonging survival of transplant models. Conclusion The compoite mandibular allografts had the availability of large bloc of living composite tissues and the good restoration of appearance and function for severe mandibular defects.