Non-carboxylic analogues of naproxen: design, synthesis, and pharmacological evaluation of some 1,3,4-oxadiazole/thiadiazole and 1,2,4-triazole derivatives |
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Authors: | Amir Mohammad Kumar Harish Javed Sadique A |
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Institution: | Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi, India. mamir_s2003@yahoo.co.in |
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Abstract: | A series of substituted 1,3,4-oxadiazole (2-7 and 14-19), 1,2,4-triazole (20-25), and 1,3,4-thiadiazole (26-31) derivatives of naproxen have been synthesized by cyclization of 2-(6-methoxy-2-naphthyl)propanoic acid hydrazide 1 and N(1)2-(6-methoxy-2-naphthyl) propanoyl]-N(4)-alkyl/aryl-thiosemicarbazides (8-13) under various reaction conditions. All the compounds were screened for their anti-inflammatory activity by carrageenan-induced rat paw edema test method. Compounds showing high anti-inflammatory activity were also tested for their analgesic, ulcerogenic, and lipid peroxidation. Few of the synthesized compounds showed significant anti-inflammatory and analgesic activities along with reduced ulcerogenic effect and lipid peroxidation. |
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Keywords: | Anti‐inflammatory Naproxen 1 3 4‐Oxadiazoles Thiadiazoles 1 2 4‐Triazoles |
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