| 人外周血淋巴细胞电压依赖性钾通道电流的记录及其特性 |
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| 引用本文： | 何艳,李长平,张文杰,孙小霞,钟国赣. 人外周血淋巴细胞电压依赖性钾通道电流的记录及其特性[J]. 吉林大学学报(医学版), 1999, 0(2) |
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| 作者姓名： | 何艳 李长平 张文杰 孙小霞 钟国赣 |
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| 作者单位： | 基础医学院生理教研室!长春，130021(何艳，张文杰，孙小霞，钟国赣)，第二临床学院血液科(李长平) |
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| 摘 要： | 目的：观察人外周血淋巴细胞膜上电压依赖性钾通道的特性。方法：膜片钳记录方法。结果：观察到该通道的最小激活电压为－38．6±2．1mV。复极过程中通道关闭常数为109．25±8．5ms，并可被10mmol／L的TEA所阻断。结论：人外周血淋巴细胞膜上存在着电压依整性钾电流，其物性与神经和肌肉细胞膜上的延迟整流性钾电流相类似。
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| 关 键 词： | 淋巴细胞 电压依赖性钾通道 膜片钳 |
Recording and characteristic allalysis of potassium channel in human peripheral lymphocytes |
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| He Ya,Li Changping,Zhang Wenjie,Sun Xiaoxia,Zhong Guogan. Recording and characteristic allalysis of potassium channel in human peripheral lymphocytes[J]. Journal of Jilin University: Med Ed, 1999, 0(2) |
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| Authors: | He Ya Li Changping Zhang Wenjie Sun Xiaoxia Zhong Guogan |
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| Abstract: | Objective: TO observe the characteristics of vitage--dependent K+ channel in human Peripherallymphocytes. Methods: Patch-clamp recording technique was used. Results:We observed that the activated voltage of K+ channel was 38. 6±2. 1 mV and the time constant of channel closing was 109. 25 IS. 5 ms,and itcould be blocked by 10 mmol/L TEA. Conclusion: There was voltage~deperident K+ channel in human Peripheallymphocytes,and it resembled the delayed rectifier K+ channel of nerve and muscle. |
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| Keywords: | lymphocyte voltage-dependent K~+ channel phtch-clamp |
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