| 培美曲塞二线治疗老年晚期非小细胞肺癌的临床观察 |
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| 引用本文： | 龚志敏,孙秋实,杜珂. 培美曲塞二线治疗老年晚期非小细胞肺癌的临床观察[J]. 陕西肿瘤医学, 2012, 0(10): 2075-2077 |
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| 作者姓名： | 龚志敏 孙秋实 杜珂 |
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| 作者单位： | [1]襄阳市中心医院肿瘤科,湖北襄阳441021 [2]武汉大学医学院研究生院,湖北武汉430073 |
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| 摘 要： | 目的：探讨培美曲塞二线治疗老年晚期非小细胞肺癌的疗效及不良反应。方法：老年晚期非小细胞肺癌患者34例,采用培美曲塞500 mg/m2,静脉滴注,第1天;21d为1周期,至少2周期后评价疗效。结果：有效率（RR）为14.7%,中位TTP 3.2个月,中位生存期7.9个月。主要毒副反应为骨髓抑制及消化道反应。结论：培美曲塞二线治疗老年晚期非小细胞肺癌的近期疗效较好,且患者耐受性好,值得临床推广。
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| 关 键 词： | 非小细胞肺癌 化疗 培美曲塞 |
Effect of pemetrexed in the second line treatment elderly patients with advanced non-small cell lung cancer |
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| GONG Zhimin,SUN Qiushi,DU Ke. Effect of pemetrexed in the second line treatment elderly patients with advanced non-small cell lung cancer[J]. Shaanxi Oncology Medicine, 2012, 0(10): 2075-2077 |
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| Authors: | GONG Zhimin SUN Qiushi DU Ke |
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| Affiliation: | 1Departmentment of Oncology,Xiangyang Hospital,Tongji Medical Colledge,Huazhong University of Science and Technology,Hubei Xiangyang 441021,China;2Medical Colledge of Wuhan University,Hubei Wuhan 430073,China. |
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| Abstract: | Objective：To evaluate the efficacy and the side-effects of pemetrexed as second-line treatment of elderly patients with advanced non-small cell lung cancer.Methods： Thirty-four elderly patients with advanced non-small cell lung cancer accepted the chemotherapy of pemetrexed 500mg/m2 on day 1.Three weeks as a circle.The effic acy and the side-effects were evaluated at least after two circles.Results： The total effective rate was 14.7%.The median time to progress was 3.2 months and the median survival was 7.9 months.The main side-effects were myelosuppression,nausea and vomiting.Conclusion： Pemetrexed in the second line of treatment of elderly patients with advanced non-small cell lung cancer is effective and with low side-effects. |
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| Keywords: | non-small cell lung cancer chemotherapy pemetrexed |
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